{"created":"2023-05-15T14:33:24.862417+00:00","id":43334,"links":{},"metadata":{"_buckets":{"deposit":"c61d85f9-fb14-433e-8637-f54723af374a"},"_deposit":{"created_by":1,"id":"43334","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43334"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043334","sets":["1"]},"author_link":["431071","431069","431068","431070"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-11","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"245","bibliographicPageStart":"237","bibliographicVolumeNumber":"43","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We here investigated and reported the effects of beer drinking on radiation-induced chromosome aberrations in blood lymphocytes. Human blood that was collected either before or after drinking a 700 ml beer was in vitro irradiated with 200 kVp X rays or 50 keV/micro carbon ions. The relation between the radiation dose and the aberration frequencies (fragments and dicentrics) was significantly (p < 0.05) lower for lymphocytes collected 3 h after beer drinking than those before drinking. Fitting the dose response to a linear quadratic model showed that the alpha term of carbon ions was significantly (p < 0.05) decreased by beer drinking. A decrease of dicentric formation was detected as early as 0.5 h after beer drinking, and lasted not shorter than 4.5 h. The mitotic index of lymphocytes was higher after beer drinking than before, indicating that a division delay would not be responsible for the low aberrations induced by beer drinking. An in vitro treatment of normal lymphocytes with 0.1 M ethanol, which corresponded to a concentration of 6-times higher than the maximum ethanol concentration in the blood after beer drinking, reduced the dicentric formation caused by X-ray irradiation, but not by carbon-ion irradiation. The beer-induced reduction of dicentric formation was not affected by serum. It is concluded that beer could contain non-ethanol elements that reduce the chromosome damage of lymphocytes induced by high-LET radiation.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Monobe, Manami"}],"nameIdentifiers":[{"nameIdentifier":"431068","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"431069","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"物部 真奈美","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431070","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"431071","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Drinking Beer Reduces Radiation-induced Chromosome Aberrations in Human Lymphocytes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Drinking Beer Reduces Radiation-induced Chromosome Aberrations in Human Lymphocytes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2004-01-25"},"publish_date":"2004-01-25","publish_status":"0","recid":"43334","relation_version_is_last":true,"title":["Drinking Beer Reduces Radiation-induced Chromosome Aberrations in Human Lymphocytes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:28:32.341730+00:00"}