@article{oai:repo.qst.go.jp:00043316,
 author = {Mizuno, Hideyuki and Tomitani, Takehiro and Kanazawa, Mitsutaka and Kitagawa, Atsushi and Pawelke, Jorg and Iseki, Yasushi and Urakabe, Eriko and Suda, Mitsuru and Kawano, Akihiro and Iritani, Riichirou and Matsushita, Satoru and Inaniwa, Taku and Nishio, Teiji and Furukawa, Shigeo and Ando, Koichi and Nakamura, Yuzuru and Kanai, Tatsuaki and 水野 秀之 and 富谷 武浩 and 金澤 光隆 and 北川 敦志 and Ｊｏｒｇ Ｐａｗｅｌｋｅ and 井関 康 and 新谷 恵理子 and 須田 充 and 河野 明広 and 入谷 理一郎 and 松下 悟 and 稲庭 拓 and 西尾 禎治 and 古川 重夫 and 安藤 興一 and 中村 譲 and 金井 達明},
 journal = {Physics in Medicine and Biology},
 month = {Jul},
 note = {Washout of 10C and 11C implanted by radioactive beams in brain and thigh muscle of rabbits was studied. The biological washout effect in living body is important in the range verification system or three-dimensional volume imaging in heavy ion therapy. Positron emitter beams were implanted in the rabbit and the annihilation gamma-rays were measured by in situ positron camera which consisted of a pair of scintillation cameras set on either side of the target. The ROI (region of interest) was set as a two-dimensional position distribution and the time-activity curve of the ROI was measured. Experiments were done under two conditions: live and dead. By comparing the two sets of measurement data, it was deduced that there are at least three components in the washout process. Time-activity curves of both brain and thigh muscle were clearly explained by the three-component model analysis. The three components ratios (and wash out half-lives) were 35 % (2.0 s), 30 % (140 s) and 35 % (10191 s) for brain and 30 % (10 s), 19 % (195 s) and 52 % (3175 s) for thigh muscle. The washout effect must be taken into account for the verification of treatment plans by means of positron camera measurements.},
 pages = {2269--2281},
 title = {Washout measurement of radioisotope implanted by radioactive beams in the rabbit},
 volume = {48},
 year = {2003}
}