@article{oai:repo.qst.go.jp:00043303, author = {Wu, Honglu and Furusawa, Yoshiya and George, Kerry and Kawata, Tetsuya and A, Cucinotta Francesca and ウー ホングル and 古澤 佳也 and ジョージ ケリー and 川田 哲也 and クシノッタ フランク}, issue = {6}, journal = {Advances in Space Research}, month = {Mar}, note = {Confluent human fibroblast cells were exposed to 6 Gy g-rays or 200 MeV/nucleon Fe ions at 0.7 or 3 Gy. The cells were allowed to repair for 24 hours after exposure and chromosomes were collected using a premature chromosome condensation technique with calyculin-A. Chromosome aberrations were analyzed using the multicolor FISH (mFISH) technique that allows identification of both complex and truly incomplete exchanges. Results showed that both doses of the Fe ions produced higher ratios of complex to simple exchanges and lower ratio of complete to incomplete exchanges than the 6 Gy g-exposure. The ratios of aberration yields were similar for the two doses of Fe ions. After 0.7 Gy of Fe ions, most complex aberrations were found to involve three or four chromosomes, indicating this is the maximum number of chromosome domains traversed by a single Fe ion track.}, pages = {1537--1542}, title = {M-Fish analysis of chromosome aberrations in human fibroblasts exposed to energetic iron ions in vitro}, volume = {31}, year = {2003} }