{"created":"2023-05-15T14:33:20.458200+00:00","id":43235,"links":{},"metadata":{"_buckets":{"deposit":"d6dd2eb6-b9b3-4618-b036-1d51a452a090"},"_deposit":{"created_by":1,"id":"43235","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43235"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043235","sets":["1"]},"author_link":["430109","430115","430107","430114","430106","430110","430111","430108","430105","430113","430112"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"49","bibliographicPageStart":"43","bibliographicVolumeNumber":"503","bibliographic_titles":[{"bibliographic_title":"Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Mouse Pc-1 (Ms6-hm) is a hypervariable minisatellite locus that is unstable\nduring intergenerational transmission.  This hyper-instability of Pc-1 is\nuseful for detecting germline mutation using a small number of experimental\nanimals, although its molecular mechanism has not yet been elucidated.  We\nexamined the effect of severe combined immune deficiency (SCID) mutation on\nthe spontaneous germline mutation at the Pc-1 locus using the CB17 mouse\nstrain.  Our results showed that the frequency of spontaneous germline\nmutation at Pc-1 in the offspring of wild-type parents was 9.7%.In F1\nbetween SCID male and wild-type female, however, the frequency of germline\nmutation was drastically increased to 42.3%. When SCID female mice were \nmated with wild-type male, the frequency of germline mutation in F1 was \nslightly increased to 13.6%. These results suggest that DNA protein kinase\n catalytic subunit (DNA-PKcs), deficiency of which causes SCID mutation, \nplays an important role in the stable transmission of a genome containing \nhypervariable tandem repeats to progeny in male germ cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0027-5107","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamauchi, Masatake"}],"nameIdentifiers":[{"nameIdentifier":"430105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"430106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuji, Satsuki"}],"nameIdentifiers":[{"nameIdentifier":"430107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Terada, Minako"}],"nameIdentifiers":[{"nameIdentifier":"430108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasanuma, Motoe"}],"nameIdentifiers":[{"nameIdentifier":"430109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"430110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内 正剛","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"辻 さつき","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"寺田 美奈子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430115","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of SCID mutation on the occurrence of mouse Pc-1 (Ms6-hm) germline mutations.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of SCID mutation on the occurrence of mouse Pc-1 (Ms6-hm) germline mutations."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-11-06"},"publish_date":"2003-11-06","publish_status":"0","recid":"43235","relation_version_is_last":true,"title":["Effect of SCID mutation on the occurrence of mouse Pc-1 (Ms6-hm) germline mutations."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:29:41.959577+00:00"}