@article{oai:repo.qst.go.jp:00043235,
 author = {Yamauchi, Masatake and Nishimura, Mayumi and Tsuji, Satsuki and Terada, Minako and Sasanuma, Motoe and Shimada, Yoshiya and 山内 正剛 and 西村 まゆみ and 辻 さつき and 寺田 美奈子 and 島田 義也},
 journal = {Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research},
 month = {},
 note = {Mouse Pc-1 (Ms6-hm) is a hypervariable minisatellite locus that is unstable
during intergenerational transmission.  This hyper-instability of Pc-1 is
useful for detecting germline mutation using a small number of experimental
animals, although its molecular mechanism has not yet been elucidated.  We
examined the effect of severe combined immune deficiency (SCID) mutation on
the spontaneous germline mutation at the Pc-1 locus using the CB17 mouse
strain.  Our results showed that the frequency of spontaneous germline
mutation at Pc-1 in the offspring of wild-type parents was 9.7%.In F1
between SCID male and wild-type female, however, the frequency of germline
mutation was drastically increased to 42.3%. When SCID female mice were 
mated with wild-type male, the frequency of germline mutation in F1 was 
slightly increased to 13.6%. These results suggest that DNA protein kinase
 catalytic subunit (DNA-PKcs), deficiency of which causes SCID mutation, 
plays an important role in the stable transmission of a genome containing 
hypervariable tandem repeats to progeny in male germ cells.},
 pages = {43--49},
 title = {Effect of SCID mutation on the occurrence of mouse Pc-1 (Ms6-hm) germline mutations.},
 volume = {503},
 year = {2002}
}