{"created":"2023-05-15T14:33:19.791373+00:00","id":43220,"links":{},"metadata":{"_buckets":{"deposit":"e5f6d99c-0bfb-4abd-9f8c-8b428b5b4407"},"_deposit":{"created_by":1,"id":"43220","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43220"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043220","sets":["1"]},"author_link":["429986","429978","429984","429973","429982","429975","429980","429983","429972","429981","429977","429979","429976","429985","429971","429974"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"430","bibliographicPageStart":"423","bibliographicVolumeNumber":"79","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: Ras activation is one of the major mechanisms for the development\nof murine thymic lymphomas by radiation and chemical carcinogens.  To gain\ninsight into the relationship between genetic susceptibility and ras gene\nmutation, the frequency and spectrum of ras gene mutation was examined in\nthymic lymphomas from susceptible and resistant mice.\nMaterials and methods: K- and N-ras mutations in thymic lymphomas that arose\nin X-ray-irradiated and N-ethyl-N-nitrosourea (ENU)-treated mice of\nsusceptible C57BL/6, rather resistant C3H, and their hybrid B6C3F1, were\nanalyzed by PCR-SSCP and subsequent DNA sequencing.\nResults: C57BL/6 exhibited a higher incidence of thymic lymphomas after\nexposure to X-rays and ENU than C3H, with B6C3F1 being intermediate. K-ras\ngene mutations occurred frequently in the pathogenesis of ENU-induced thymic\nlymphomas in susceptible C57BL/6 as opposed to resistant C3H.  The ras\nmutations were more frequent in ENU-induced thymic lymphomas than\nX-ray-induced thymic lymphomas and with the latter, there was no clear\nevidence for strain differences, suggesting that the genetic susceptibility\nto X-rays was independent of ras activation. The mutations of K-ras in\nthymic lymphomas from C57BL/6 were predominantly GGT-to-GAT in codon 12,\nwhereas this mutation type was never found in those from C3H.  No strain\ndifference was observed in the nucleotide sequence or expression levels of\nO6-alkylguanine alkyltransferase, indicating that the enzyme did not account\nfor the genetic susceptibility to ras activation.\nConclusions: The results indicate that there is a clear strain- and\ncarcinogen-dependency of K-ras mutation, and that the frequency of ras\nmutation might determine the genetic susceptibility to ENU-induced\nlymphomagenesis, whereas the pathways(s) independent of ras activation might\ndetermine the susceptibility to X-ray-induced lymphomagenesis.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"429971","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"429972","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"429973","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogiu, Toshiaki"}],"nameIdentifiers":[{"nameIdentifier":"429974","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujimoto, Hirokazu"}],"nameIdentifiers":[{"nameIdentifier":"429975","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubo, Ayumi"}],"nameIdentifiers":[{"nameIdentifier":"429976","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Junya"}],"nameIdentifiers":[{"nameIdentifier":"429977","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tano, Keizou"}],"nameIdentifiers":[{"nameIdentifier":"429978","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshinaga, Shinji"}],"nameIdentifiers":[{"nameIdentifier":"429979","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429980","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429981","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429982","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"荻生 俊昭","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429983","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保 歩","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"永井 絢也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉永 信治","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"429986","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-10-22"},"publish_date":"2003-10-22","publish_status":"0","recid":"43220","relation_version_is_last":true,"title":["Genetic susceptibility to thymic lymphomas and K-ras gene mutation in mice after exposure to X-rays and N-ethyl-N-nitrosourea"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:29:52.444797+00:00"}