@article{oai:repo.qst.go.jp:00043017,
 author = {Oya, Natsuo and Sasai, Keisuke and Shibata, Toru and Takagi, Takehisa and Shibuya, Keiko and Koike, Sachiko and Nojima, Kumie and Furusawa, Yoshiya and Ando, Koichi and Hiraoka, Masahiro and 笹井 啓資 and 小池 幸子 and 野島 久美恵 and 古澤 佳也 and 安藤 興一 and 平岡 真寛},
 journal = {Journal of Radiation Research},
 month = {},
 note = {We compared the tumor reoxygenation patterns in three different murine tumor cell lines after X-irradiation with those after carbon-beam irradiation using a heavy-ion medical accelerator (HIMAC) system. The tumors of the cell lines SCCVII, SCCVII-variant-1 and EMT6 on the hind legs of mice received local priming irradiation with a carbon-beam (8 Gy, 73 keV/um in LET, 290 MeV/u, 6 cm SOBP) or X-rays (13 Gy, 250 kVp). After various intervals, the mice were given whole-body test irradiation (16 Gy, 250 kVp X-ray) either in air or after they were killed. The hypoxic fractions were estimated as the proportions of the surviving fractions of the tumors in killed mice to those in air-breathing mice. In the SCCVII tumors, the hypoxic fractions at 0.5 h were 50% and 21% (p < 0.05) after the priming X-irradiation and carbon-beam irradiation, respectively. In the SCCVII-variant-1 tumors, the hypoxic fractions were 85% and 82% at 0.5 h, 84% and 20% at 12 h (p < 0.01), and 21% and 31% at 24 h after X-ray and after carbon-beam irradiation, respectively. In the EMT6 tumors, the reoxygenation patterns after X-irradiation and carbon-beam irradiation were quite similar. We concluded that the reoxygenation pattern differed among the three tumor cell lines, and that reoxygenation tended to occur more rapidly after carbon-beam irradiation than after X-irradiation for SCCVII and SCCVII-variant-1tumors.},
 pages = {131--141},
 title = {Time course of reoxygenation in experimental murine tumors after carbon-beam and x-ray irradiation},
 volume = {42},
 year = {2001}
}