{"created":"2023-05-15T14:33:05.377502+00:00","id":42901,"links":{},"metadata":{"_buckets":{"deposit":"f7f54c73-eb3c-438f-8de6-50db7d5e51bd"},"_deposit":{"created_by":1,"id":"42901","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"42901"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00042901","sets":["1"]},"author_link":["426965","426966","426970","426964","426968","426969","426967","426963"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"77","bibliographicPageStart":"73","bibliographicVolumeNumber":"504","bibliographic_titles":[{"bibliographic_title":"FEBS Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Treatment of Chinese hamster ovary K1 cells with phosphatidylserine (PS) caused typical　apoptosis with distinct morphological and biochemical features in a dose- and time-dependent manner. However, unlike camptothecin-induced apoptosis, changes in mitochondrial transmembrane\npotential were not observed. In addition, cytochrome c release did not occur in PS-induced apoptosis. A pan caspase inhibitor, Z-VAD, significantly inhibited the apoptosis, but inhibitors of caspase-1, -3, -8 and -9 did not. Activities of caspase-1, -3, -8 and -9 were increased by\ntreatment of the cells with camptothecin, but not with PS. These results suggest that PS-induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c, in a manner independent of caspase-1, -3, -8 and -9. \n","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0014-5793","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyato, Yasuyuki"}],"nameIdentifiers":[{"nameIdentifier":"426963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ibuki, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"426964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohyama, Harumi"}],"nameIdentifiers":[{"nameIdentifier":"426965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Takeshi"}],"nameIdentifiers":[{"nameIdentifier":"426966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Goto, Rensuke"}],"nameIdentifiers":[{"nameIdentifier":"426967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"宮戸 靖幸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大山 ハルミ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 武","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"426970","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Phosphatidylserine induces apoptosis in CHO cells without mitochondrial  dysfunction in a manner dependent on caspases other than caspases-1, -3, -8  and -9.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Phosphatidylserine induces apoptosis in CHO cells without mitochondrial  dysfunction in a manner dependent on caspases other than caspases-1, -3, -8  and -9."}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2002-06-06"},"publish_date":"2002-06-06","publish_status":"0","recid":"42901","relation_version_is_last":true,"title":["Phosphatidylserine induces apoptosis in CHO cells without mitochondrial  dysfunction in a manner dependent on caspases other than caspases-1, -3, -8  and -9."],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:33:36.697112+00:00"}