@article{oai:repo.qst.go.jp:00042901,
 author = {Miyato, Yasuyuki and Ibuki, Yuko and Ohyama, Harumi and Yamada, Takeshi and Goto, Rensuke and 宮戸 靖幸 and 大山 ハルミ and 山田 武},
 journal = {FEBS Letters},
 month = {},
 note = {Treatment of Chinese hamster ovary K1 cells with phosphatidylserine (PS) caused typical　apoptosis with distinct morphological and biochemical features in a dose- and time-dependent manner. However, unlike camptothecin-induced apoptosis, changes in mitochondrial transmembrane
potential were not observed. In addition, cytochrome c release did not occur in PS-induced apoptosis. A pan caspase inhibitor, Z-VAD, significantly inhibited the apoptosis, but inhibitors of caspase-1, -3, -8 and -9 did not. Activities of caspase-1, -3, -8 and -9 were increased by
treatment of the cells with camptothecin, but not with PS. These results suggest that PS-induced apoptosis occurs without the collapse of mitochondrial transmembrane potential and without the release of cytochrome c, in a manner independent of caspase-1, -3, -8 and -9.},
 pages = {73--77},
 title = {Phosphatidylserine induces apoptosis in CHO cells without mitochondrial  dysfunction in a manner dependent on caspases other than caspases-1, -3, -8  and -9.},
 volume = {504},
 year = {2001}
}