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G2-Chromosome Aberarions Induced by High-LET Radiations.
https://repo.qst.go.jp/records/42869
https://repo.qst.go.jp/records/4286988d33142-6f94-445f-84e4-eec35591182f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2002-02-12 | |||||
| タイトル | ||||||
| タイトル | G2-Chromosome Aberarions Induced by High-LET Radiations. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kawata, Tetsuya
× Kawata, Tetsuya× Durante, Marco× Furusawa, Yoshiya× George, Kerry× Ito, Hisao× Wu, Honglu× A, Cucinotta Francesca× 川田 哲也× 古澤 佳也× ジョージ ケリー× 伊東 久夫× ウー ホングル× クシノッタ フランク |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We report measurements of initial G2-chromatid breaks in normal human fibroblasts exposed to various types of high-LET particles. Exponentially growing AG 1522 cells were exposed to gamma-rays or heavy ions. Chromosomes were prematurely condensed by calyculin A. Chromatid-type breaks and isochromatid-type breaks were scored separately. The dose response curves for the induction of total chromatid breaks (chromatid-type + isochromatid-type) and chromatid-type breaks were linear for each type of radiation. However, dose response curves for the induction of isochromatid-type breaks were linear for high-LET radiations and linear-quadratic for gamma-rays. Relative biological effectiveness (RBE), calculated from total breaks, showed a LET dependent tendency with a peak at 55 keV/um silicon (2.7) or 80 keV/um carbon (2.7) and then decreased with LET (1.5 at 440 keV/um). RBE for chromatid-type break peaked at 55 keV/um (2.4) then decreased rapidly with LET. The RBE of 440 keV/um iron particles was 0.7. The RBE calculated from induction of isochromatid-type breaks was much higher for high-LET radiations. It is concluded that the increased production of isochromatid-type breaks, induced by the densely ionizing track structure, is a signature of high-LET radiation exposure. | |||||
| 書誌情報 |
Advances in Space Research 巻 27, p. 383-391, 発行日 2001 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0273-1177 | |||||
