WEKO3
アイテム
Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation
https://repo.qst.go.jp/records/2003004
https://repo.qst.go.jp/records/20030040d74820d-9f9f-4a26-8ca0-81c537e71c58
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||
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| 公開日 | 2026-03-12 | |||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||
| タイトル | Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation | |||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||
| 著者 |
Lidan Zhang
× Lidan Zhang
× Takayuki Kaji
× Ayasa Nakamura
× Nagomu Maesawa
× Kanako Iwamori
× Jiayao Xu
× Akiyoshi Uezumi
× Daisuke Kamimura
× Murakami Masaaki
× Werner Muller
× Atsushi Kubo
× Takayuki Akimoto
× So-ichiro Fukada
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||
| 内容記述 | Quiescent muscle stem cells (MuSCs) respond to exercise; however, the coordinated regulation of increased loading, exerkines, and quiescence signaling remains unclear. We found that increased loading reduces calcitonin receptor (CalcR) expression, and forced activation of protein kinase A (PKA), a downstream of CalcR signaling, suppresses MuSC proliferation. Although MuSC-specific Calcr knockout (C-cKO) alone is insufficient, exercised C-cKO mice exhibit significant MuSC proliferation independent of increased loading. Reinforcement of CalcR signaling, either through PKA induction or Yap1 depletion, suppresses MuSC proliferation. Load-independent MuSC proliferation is also suppressed by the deletion of gp130 in C-cKO mice. Serum from exercised mice recapitulates MuSC proliferation in all analyzed muscles of sedentary C-cKO mice, which is abrogated by anti-IL-6 antibodies, and we find cross-talk between CalcR and gp130 signaling via Yap1 phosphorylation. Together, our findings reveal an integrated mechanism by which increased loading, exerkine-gp130, and CalcR signaling converge to fine-tune MuSC activity during exercise. | |||||||||||||||||||||||||||||||
| 書誌情報 |
Nature Communications (Online Only URL:http://www.nature.com/ncomms/index.html) 巻 16, 号 1, p. 10576, 発行日 2025-11 |
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||
| 収録物識別子 | 2041-1723 | |||||||||||||||||||||||||||||||
