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Changes in nuclear morphology and size in mammalian temperature-sensitive mutants
https://repo.qst.go.jp/records/2002949
https://repo.qst.go.jp/records/20029498edf3b01-a9a6-4341-8a1f-6ce5c4e0953a
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-03-09 | |||||||
| タイトル | ||||||||
| タイトル | Changes in nuclear morphology and size in mammalian temperature-sensitive mutants | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
Sugaya Kimihiko
× Sugaya Kimihiko
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Nuclear morphology alters during development and disease. Nuclear size and shape are regulated through several mechanisms. In this study, details of phenotypes of temperature-sensitive mutants, which were isolated from Chinese hamster CHO-K1 cells to identify genes responsible for the maintenance of chromosome integrity, were characterized with particular focus on changes in their nuclear size and shape. DNA replication has been implicated in a mutant exhibiting elongation of the nucleus with an increase in its ellipticity during incubation at the nonpermissive temperature of 39°C. Incubation at this temperature also resulted in nuclear enlargement in other mutants accompanied by increased DNA damage and led to a remarkable increase in cells harboring an abnormal nucleus, particularly multiple nuclei or segmented nuclei. These findings may lead to the discovery of a novel mechanism that regulates nuclear size and shape. Identification of genes responsible for these defects is highly desirable. | |||||||
| 書誌情報 |
Cell Structure and Function 発行日 2026-03 |
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