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アイテム
標的α線放出核種治療における抗腫瘍効果の分子メカニズム
https://repo.qst.go.jp/records/2002851
https://repo.qst.go.jp/records/2002851d93b9472-0c5d-4179-b087-0a06ae2f8230
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-03-02 | |||||||
| タイトル | ||||||||
| タイトル | 標的α線放出核種治療における抗腫瘍効果の分子メカニズム | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| 著者 |
大島 康宏
× 大島 康宏
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| 抄録 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Targeted α-radionuclide therapy (TAT) is a systemic therapy for cancer with cancer-targeting compounds conjugated with α-emitters. Since the linear energy transfer (LET) of α-particle is high, relative biological effectiveness is higher than low LET radiation, such as X-ray and β-particle, and the damage to the normal tissues surrounding the tumor is minimal because path-length of α-particle is short (a few cells). TAT has demonstrated remarkable therapeutic effects in patients, attracting significant attention from physicians and researchers around the world. In particular, a paper published in 2016 has shown that disseminated tumors in a patient with castration-resistant prostate cancer disappeared following treatment with an 225Ac labeled prostate specific membrane antigen ligand. So how is the powerful antitumor effect of TAT induced? The molecular mechanism of the antitumor effect of radiation is well studied in external beam radiation therapy (EBRT). However, because EBRT and TAT are fundamentally different in terms of dose-rate, irradiation uniformity, and exposure time, it is difficult to extrapolate the knowledge of EBRT to TAT. Compared to research on the development of new TAT agents, studies focusing on the radiobiology of TAT are limited, and the detailed mechanisms of its antitumor effects remain poorly understood. We have developed α-emitting meta-[211At]astato-benzylguanidine ([211At]MABG) as a novel TAT agent, and investigated radiobiological responses caused by [211At]MABG using comprehensive gene expression analysis. Here, we would like to introduce the mechanism of antitumor effects on TAT based on our studies of [211At]MABG. | |||||||
| 書誌情報 |
YAKUGAKU ZASSHI 巻 146, 号 3, p. 205-210, 発行日 2026-03 |
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| 出版者 | ||||||||
| 出版者 | 公益社団法人 日本薬学会 | |||||||
| ISSN | ||||||||
| 収録物識別子タイプ | ISSN | |||||||
| 収録物識別子 | 1347-5231 | |||||||
| DOI | ||||||||
| 識別子タイプ | DOI | |||||||
| 関連識別子 | 10.1248/yakushi.25-00146-3 | |||||||
