| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-19 |
| タイトル |
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|
タイトル |
Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty. |
|
言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Takaya Ogasawara
Kevin Xu
Abraham Z Snyder
Joel S Perlmutter
Zhude Tu
Takafumi Minamimoto
Ken-Ichi Inoue
Masahiko Takada
Ilya E Monosov
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Expectation of perceptual novelty shapes our daily decisions and has an impact on how we evaluate primary rewards. To identify the underlying circuitry, we trained subjects to choose between offers associated with varying probabilities of receiving large juice rewards and experiencing novel objects. Anticipated novelty modulated valuation by increasing both choice preference for and motivational value of large rewards. This novelty-reward interaction was reflected in a circuit comprising anterior ventral medial temporal cortex (AVMTC), implicated in detecting and predicting novelty, and orbitofrontal cortex (OFC), which receives AVMTC inputs and signals the reward value associated with visual objects. Novelty and reward signals were first detectable in AVMTC. However, OFC neurons' activity more closely reflected subjective preference across the reward-novelty offers in our task. Chemogenetic disruption of AVMTC→OFC altered the impact of expected novelty on reward valuation. These results suggest that the ventral visual system contributes to novelty-reward interactions during valuation through direct projections to prefrontal cortex. |
| 書誌情報 |
Neuron
発行日 2026-02
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1097-4199 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
41666934 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neuron.2025.12.011 |
