| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-17 |
| タイトル |
|
|
タイトル |
Comparison of supine and upright postures in carbon ion radiotherapy for pancreatic cancer: An in silico planning study |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Nomura Yusuke
Inaniwa Taku
Isozaki Tetsuro
Kurosaki Hiroki
Shinoto Makoto
山田祥岳
山田稔
横山陽一
Mizuno Hideyuki
Yonai Shunsuke
Iwata Yoshiyuki
武田篤也
Ishikawa Hitoshi
陣崎雅弘
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Background: Conducting carbon ion radiotherapy (CIRT) in upright posture has several technical advantages over that in conventional supine posture for pancreatic cancer treatment. However, few studies have investigated effects of upright positioning on anatomy and CIRT dose distributions.Purpose: This study compared anatomy and dose distributions in CIRT for pancreatic cancer between supine and upright postures.Methods: Fourteen pairs of computed tomography (CT) images obtained from asymptomatic volunteers in these postures were analyzed. Clinical target volume (CTV), organs-at-risk (OARs), and gastrointestinal gas contours were delineated within a planning volume for each CT image, and a CIRT dose distribution was calculated. The anatomical differences between these postures were evaluated by comparing volumes and 3D rendered images of the contours, while the dosimetric differences were assessed with 12 dosimetric metrics. Moreover, a proximal overlap volume of the OARs and possible change in water-equivalent path length due to gastrointestinal gas were calculated for all coplanar beam angles to compare ranges of applicable beam angles and potential range uncertainty between these postures.Results: The bowel contour volumes in the upright posture were more than 46% smaller than those in the supine posture because the bowel was shifted. The upright posture provided a smaller dose to the bowel and higher dose coverage to the CTV than the supine posture. The possible water-equivalent path length changes due to the stomach and duodenum gas decreased at most beam angles in the upright posture.Conclusions: The upright CIRT had several anatomical and dosimetric advantages for pancreatic cancer treatment over conventional supine CIRT. This technique will be useful in applying the patient-specific beam angle arrangement and precise dose delivery with reduced range uncertainty. |
| 書誌情報 |
Medical Physics
巻 53,
発行日 2026-01
|
| DOI |
|
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1002/mp.70325 |
