| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-05 |
| タイトル |
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タイトル |
Changes in yields of oxidative damages 8-hydroxy-2′-deoxyguanosine in the presence of gold nanoparticles under X-rays, protons and heavy ions |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Kusumoto Tamon
Shinoka Yoshida
Hirayama Ryoichi
Jun Kataoka
Stephane Roux
Michel Fromm
Rana Bazzi
Kodaira Satoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
ObjectivesTo clarify the mechanisms of GNPs radiosensitizing effects, we investigated changes in yields of 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is an oxidative damage marker and generated by reactions of 2′-deoxyguanosine (dG) with OH radicals in aqueous solutions.MethodsAqueous dG (Sigma Aldrich) solutions (500 μM) are irradiated with X-rays, protons and heavy ions in a wide LET range. The examined LET range is from about 2 to 600 eV/nm. After the irradiation, electrochemical detectors connected to HPLC system are employed to quantitatively evaluate changes in yields of 8-OHdG in the presence and in the absence of GNPs. The size of GNPs applied is a gold core diameter of between 2 and 3 nm.ResultsThe G value of 8-OHdG formed decreases with increasing LET, and it has the highest value under X-rays. In the presence of GNPs, the G value of 8-OHdG increases significantly under X-rays. Similar trends are seen under heavy ions, except for protons.ConclusionsThe increase of G value of 8-OHdG suggests a potential of the applicability of GNPs to particle therapies for cancer. |
| 書誌情報 |
International Journal of Radiation Biology
巻 101,
号 11,
p. 1129-1134,
発行日 2025-09
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| 出版者 |
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出版者 |
Taylor & Francis |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1362-3095 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1080/09553002.2025.2550436 |
