| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-02-10 |
| タイトル |
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|
タイトル |
Uranium micro localization in the renal proximal tubules during intimal exposure of rats to uranyl acetate |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Takeda Shino
Yakumaru Haruko
Terauchi Miyu
Ayama Kyoko
Sekizawa Oki
Nitta Kiyofumi
Numako Chiya
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The kidney is the main site of deposition of uranium (U) after exposure. The distal portion of the proximal tubules (S3 segment) are thought to be responsible for the reabsorption of U from the urine, but the dynamics of U distribution in the renal tubules has not been clearly understood. In the present study, the precise distribution of U in the S3 segment of the proximal tubules (S3 tubules) was examined in Wistar male rats during the initial phase of subcutaneous U administration (1 to 3 h post-administration of uranyl acetate, 0.5 mg/kg of body weight) by X-ray fluorescence spectrometry using high energy synchrotron radiation microbeam (SR-μXRF). At 1 h post-administration, rapid transition of U into kidney was observed; U was accumulated in the kidneys at the level of 4% of the dose. In the cross-section of the S3 tubules, U was distributed in the brush border, indicated that U was already being reabsorbed from the urine at this point. Formation of highly concentrated U in microregions with the maximum U level of around 150 μg/g was also detected in the epithelium of the S3 tubules. At 3 h post-administration, the amount of U accumulated to the kidneys was 9% of the dose, and the maximum uranium level of the micro localization in the epithelium of the S3 tubules reached above 200 μg/g. The distribution pattern of micro localization was characteristic of U and differed from those of endogenous trace elements, such as iron and zinc. These findings would be valuable information for decrporation strategies of accumulated U from the critical organ. |
| 書誌情報 |
Metallomics Research
巻 6,
号 1,
p. reg01-reg07,
発行日 2026-03
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| 出版者 |
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出版者 |
Japan Society for Biomedical Research on Trace Elements |
