| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-19 |
| タイトル |
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タイトル |
In vivo quantitative assessments with [11C]T-278, a PET imaging agent for diacylglycerol kinase gamma, in nonhuman primate brain |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yasushi Hattori
Yamasaki Tomoteru
Nagai Yuji
Okauchi Takashi
Fujinaga Masayuki
Mori Wakana
Minamimoto Takafumi
Higuchi Makoto
Tatsuki Koike
Zhang Ming-Rong
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Diacylglycerol kinase (DGK) is an enzyme catalyzing ATP-dependent conversion of diacylglycerol to phosphatidic acid. Among DGK subtypes, DGKγ is localized in the brain and plays important roles in the central nervous system, although its detailed functions remain unknown. Recently, [11C]T-278 was developed as a selective positron emission tomography (PET) imaging agent for DGKγ. This study aimed to conduct the first quantitative analysis using PET with [11C]T-278 in nonhuman primate brains. In rhesus monkeys, compartmental analyses showed superior goodness-of-fit in two-tissue compartment model than one-tissue compartment model. Full kinetic analysis of [11C]T278 yielded reliable estimates of the total distribution volume (VT) values across various brain regions, showing a strong correlation (slope = 1.07, r > 0.995) with VT value derived from Logan GA. Furthermore, time-stability analysis for VT estimations showed small variations (< 5%) between 70 and 90 min of scan durations across most regions of interest. This study provides the first in vivo visualization of DGKγ in monkey brain using quantitative PET analysis with [11C]T-278. |
| 書誌情報 |
NeuroImage
発行日 2026-01
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| 出版者 |
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出版者 |
ELSEVIER |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1095-9572 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/j.neuroimage.2026.121731 |
