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内容記述 |
Spatial and temporal resolutions of preclinical PET have been limited to around 1 mm and few seconds, which are not sufficiently fine and fast enough to visualize rapidly changing blood flow and neuronal activity in rodent models. Thus, sub-second and sub-0.5 mm resolutions imaging is one of our dreams for the next 10 years in the preclinical PET imaging field. Here, we report on our two preclinical PET scanners using depth-of-interaction technology. The first one is an ultrahigh sensitive PET, which achieved the sub-second temporal resolution. The second one is the ultrahigh resolution PET, which achieved sub-0.5 mm spatial resolution. In the workshop, we will discuss the technical challenges and solutions towards our ultimate goal of sub-second and sub-0.5 mm resolution preclinical PET imaging, which may give us new insights in our understanding of various diseases mechanisms. |
