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Prediction of tumour hypoxia by range-verification PET in particle therapy: Proof-concept in rats
https://repo.qst.go.jp/records/2002467
https://repo.qst.go.jp/records/20024676c28d6e7-890c-4354-9ecf-bf69fcb29fae
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-10-21 | |||||||
| タイトル | ||||||||
| タイトル | Prediction of tumour hypoxia by range-verification PET in particle therapy: Proof-concept in rats | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||
| 資源タイプ | conference presentation | |||||||
| 著者 |
Toramatsu Chie
× Toramatsu Chie
|
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| 抄録 | ||||||||
| 内容記述 | Abstract— Tumour hypoxia, highly influenced by tumour vasculature status, has an important implication for tumour response to radiation therapy. While tumour hypoxia status is changing during a treatment period, hypoxia PET is impractical to perform in every fractionated irradiation. On the other hand, there is a chance to extract tumour hypoxia information from the biological washout in range-verification PET, by detecting irradiation-produced positron (β+)-emitting nuclides. However, it is not clear whether the blood flow supply and washout can reflect the tumour oxygen status. Therefore, this study aimed at obtaining conclusive evidence in hypoxic tumour rat models by comparing results for range-verification PET and hypoxia PET. Glioma C6 cancer cells were transplanted into nude rats. Tumours were irradiated with a 12C ion beam, and range-verification PET was performed by a high sensitivity total-body small-animal PET system. Then the rats underwent PET imaging with a hypoxia tracer, 18F-FAZA, for tumour diagnosis. The parametric maps of washout rate obtained with range-verification PET were in good agreement with 18F-FAZA-PET images. This study demonstrated the biological washout-based diagnosis for tumour hypoxia in routine range-verification PET. | |||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||
| 内容記述 | 2025 IEEE NSS MIC RTSD | |||||||
| 発表年月日 | ||||||||
| 日付 | 2025-11-06 | |||||||
