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アイテム
老化細胞を検出・除去するRadiosenolyticsの開発 (Development of Radiosenoltics for Imaging and Removal of Senescent Cells)
https://repo.qst.go.jp/records/2002458
https://repo.qst.go.jp/records/2002458cd3ee852-f49f-4ad1-b8c6-b0985273d1c3
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-10-15 | |||||||
| タイトル | ||||||||
| タイトル | 老化細胞を検出・除去するRadiosenolyticsの開発 (Development of Radiosenoltics for Imaging and Removal of Senescent Cells) | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||
| 資源タイプ | conference presentation | |||||||
| 著者 |
Zhang Ming-Rong
× Zhang Ming-Rong
|
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| 抄録 | ||||||||
| 内容記述 | Metabotropic glutamate receptor 1 (mGluR1), a key mediator of glutamatergic signaling, is frequently overexpressed in tumor cells and is an attractive drug target for most cancers. Here, we present a targeted radiopharmaceutical therapy strategy that antagonistically recognizes mGluR1 and eradicates mGluR1+ humantumors by harnessing a small-molecule alpha (a)-emitting radiopharmaceutical, 211At-AITM. A single doseof 211At-AITM (2.96 MBq) in mGluR1+ cancers exhibits long-lasting in vivo antitumor efficacy across sevensubtypes of four of the most common tumors, namely, breast cancer, pancreatic cancer, melanoma, and colon cancers, with little toxicity. Moreover, complete regression of mGluR1+ breast cancer and pancreatic cancer is observed in approximate 50% of tumor-bearing mice. Mechanistically, the functions of 211At-AITM areuncovered in downregulating mGluR1 oncoprotein and inducing senescence of tumor cells with a reprogrammed senescence-associated secretory phenotype. Our findings suggest a-radiopharmaceutical therapywith 211At-AITM can be a useful strategy for mGluR1+ pan-cancers, regardless of their tissue of origin | |||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||
| 内容記述 | Cancer Innovation, Wisdom Gathers in Tianjin Summit | |||||||
| 発表年月日 | ||||||||
| 日付 | 2025-10-18 | |||||||
