WEKO3
アイテム
Development of an Antigen-Independent Dendritic Cell Therapy Using Tumor-Bin ding Antibodies Induced by Radiation Therapy
https://repo.qst.go.jp/records/2002346
https://repo.qst.go.jp/records/200234607818411-3265-4468-8deb-74a58acc9521
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-11-12 | |||||||||
| タイトル | ||||||||||
| タイトル | Development of an Antigen-Independent Dendritic Cell Therapy Using Tumor-Bin ding Antibodies Induced by Radiation Therapy | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||||
| 資源タイプ | conference presentation | |||||||||
| 著者 |
武島 嗣英
× 武島 嗣英
× 長谷川 純崇
|
|||||||||
| 抄録 | ||||||||||
| 内容記述 | Radiation therapy not only kills tumor cells but also modulates the immune m icroenvironment. In a B16F10-OVA tumor model, we found that tumor-binding an tibodies (TBAs) increased in serum seven days after local X-ray irradiation at 8 Gy. Here, we developed an antigen-independent dendritic cell (DC) thera py using these TBAs. Serum collected on day 7 post-irradiation was used to i solate TBAs, which were incubated with bone marrow-derived DCs (BMDCs) via F c receptor binding to generate TBA-loaded DCs (TBA-DCs). These showed enhanc ed antigen uptake and maturation. Intratumoral injection of TBA-DCs suppress ed tumor growth and induced tumor-specific cytotoxic T lymphocytes (CTLs) mo re effectively than control DCs. As TBAs reflect each host's tumor antigens, this strategy enables DCs to present patient-specific antigens without prio r profiling. This feature makes it suitable for tumors with unknown or varia ble antigens. By combining radiation-induced antibody responses with DC ther apy, TBA-DC offers a promising approach to personalized cancer immunotherapy and may have future clinical potential. | |||||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||||
| 内容記述 | 第84回日本癌学会学術総会 | |||||||||
| 発表年月日 | ||||||||||
| 日付 | 2025-09-26 | |||||||||
