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内容記述 |
Introduction: Although many studies have suggested that abnormal sleep may affect resting functional connectivity[1,2], the impact of normal everyday sleep quality on connectivity has been largely ignored. This study investigates the impact of natural sleep quality on the subsequent day’s resting-state functional MRI (rsfMRI) connectivity patterns.Materials & Methods: Fourteen healthy female subjects participated in two sets of tests that included sleep assessments and MRI scans across two consecutive days. Sleep quality was objectively measured using a portable EEG monitor in the participant's home environment. The ROI-to-ROI connectivity was calculated with the CONN toolbox. Multi-regression analysis was used to investigate the relationship between the ROI-to-ROI connectivity and the objective sleep indices. The relationship between the sleep indices and the connectivities was analyzed using repeated measures correlation analysis.Results and Discussion: Changes to the wake after sleep onset (WASO) and spindle duration (SpD) indexes were correlated with changes in the connectivity between the default mode network (DMN) and salience network (SN). An increase in the SpD index was found to be related to an increase in the connectivity within the SN (Fig.1). Subjects that had large changes in connectivity tended to have substantial changes in WASO between the two measurements. In contrast, even though there may have been a substantial change in connectivity for a particular subject, the accompanying change in SpD was relatively small (Fig.2).Conclusions: The results suggest that the WASO index is related to the DMN-SN interconnectivity, with the observed alteration in connectivity potentially arising from day-to-day variations in the index. In contrast, changes in connectivity associated with the SpD index may reflect differences between individuals rather than daily fluctuations. |
