| アイテムタイプ |
会議発表用資料 / Presentation(1) |
| 公開日 |
2025-09-29 |
| タイトル |
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タイトル |
P53-independent bystander effects via secreted factors between carbon-ion irradiated tumor and unirradiated normal cells |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6670 |
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資源タイプ |
conference poster |
| 著者 |
Suzuki Masao
鈴木 雅雄
Sai Sei
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| 抄録 |
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内容記述 |
Communication from carbon-ion irradiated tumor to unirradiated normal cells is one of major concerns for heavy-ion radiotherapy. Human glioblastoma cells (mutated type <I>P53</I> )and human lung adenocarcinoma cells (wild-type <I>P53</I> ) were irradiated with carbon-ion microbeams (LET= 103keV/μm) generated with Takasaki Ion Accelerators for Advanced Radiation Application, National Institutes for Quantum Science and Technology (QST). The medium from the irradiated tumor cells was added to the flask inoculated on unirradiated normal human skin fibroblasts (wild-type <I>P53</I> ). The medium transfer resulted in increasing both cell killing and gene mutation in the normal cells. Furthermore, induced biological effects returned to control levels when using ascorbic acid (AsA), not dimethyl sulfoxide. There is clear evidence that the medium from the irradiated tumor cells enable to induce damage in the unirradiated normal cells via bystander effect mediated by secreted factor(s), which are scavenged by AsA. And <I>P53</I>-gene status of irradiated tumor cells is not participating in inducing secreted-factor-mediated bystander effects. |
| 会議概要（会議名, 開催地, 会期, 主催者等） |
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内容記述 |
第84回日本癌学会学術総会 |
| 発表年月日 |
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日付 |
2025-09-25 |
