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婦人科がんにおける重粒子線治療前後のHLA発現
https://repo.qst.go.jp/records/2002252
https://repo.qst.go.jp/records/2002252d725ad2d-b10c-49c3-99c7-3b3180c7fd6a
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-09-29 | |||||||||
| タイトル | ||||||||||
| タイトル | 婦人科がんにおける重粒子線治療前後のHLA発現 | |||||||||
| 言語 | ja | |||||||||
| 言語 | ||||||||||
| 言語 | jpn | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||||
| 資源タイプ | conference presentation | |||||||||
| 著者 |
長谷川 純崇
× 長谷川 純崇
× 中島 菜花子
|
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| 抄録 | ||||||||||
| 内容記述 | Human leukocyte antigen (HLA) is a major histocompatibility complex (MHC) class I molecule in human and is critical for anti-tumor immunity in the host. To investigate the impact of heavy-ion irradiation on anti-tumor immune responses in gynecologic cancers, we conducted immunohistochemical analyses to evaluate protein expression of HLA-I on cell surface of clinical samples from the patients of uterine cervical adeno/adenocarcinoma (UCAA) that underwent heavy-ion radiotherapy (HIRT). Of the 55 UCAA patients, 31 who underwent pre-HIRT and post-12 Gy-HIRT tumor biopsies were used for this study. All clinical samples were obtained from a single center. Of 31 samples examined, 93% of the samples were positive for HPV. Pre-HIRT HLA-I positive (over 50% of cells) was 4 and partial positive (5-50% of cells) was 13 samples. In contrast, post-HIRT HLA-I positive was 14 and partial positive was 10 samples. This study demonstrated that HIRT can restore immune recognition in UCAA cells, warranting favorable combination with immunotherapy. This abstract is an encore abstract. | |||||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||||
| 内容記述 | 第84回日本癌学会学術総会 | |||||||||
| 発表年月日 | ||||||||||
| 日付 | 2025-09-25 | |||||||||
