| アイテムタイプ |
会議発表用資料 / Presentation(1) |
| 公開日 |
2025-06-30 |
| タイトル |
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|
タイトル |
Optimal radiation dose to induce the abscopal effect through the combination of carbon-ion radiotherapy and immune checkpoint therapy |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_c94f |
|
資源タイプ |
conference presentation |
| 著者 |
Liqiu Ma
Xie Lin
Osada Kensuke
Yoshida Yukari
Takahashi Akihisa
Shimokawa Takashi
|
| 抄録 |
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内容記述 |
Although carbon-ion radiotherapy (CIRT) has shown good outcomes, metastasis control remains a crucial issue. This study evaluated the abscopal effect of combining CIRT with immune checkpoint therapy (ICT) at different radiation doses. Tumor-bearing mice were treated with 3 Gy or 10 Gy of CIRT, followed by ICT. High-dose CIRT combined with anti-CTLA4 antibody showed excellent local control but no abscopal effect. In contrast, 3 Gy CIRT with anti-CTLA4 antibody reduced the volume of distant tumors by 40%, suggesting an optimal dose for inducing the abscopal effect. |
| 会議概要（会議名, 開催地, 会期, 主催者等） |
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|
内容記述 |
The 42nd International Conference of Photopolymer Science and Technology (ICPST-42) |
| 発表年月日 |
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|
日付 |
2025-06-25 |
