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アイテム
Role of Ca2+ signaling for Oscillation of Circadian Transcriptional Circuits
https://repo.qst.go.jp/records/2002201
https://repo.qst.go.jp/records/2002201b4d8aa76-5eec-4f30-86c4-8e855f647570
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-06-17 | |||||||
| タイトル | ||||||||
| タイトル | Role of Ca2+ signaling for Oscillation of Circadian Transcriptional Circuits | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||
| 資源タイプ | conference presentation | |||||||
| 著者 |
Kon Naohiro
× Kon Naohiro
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| 抄録 | ||||||||
| 内容記述 | Our group is focusing on roles of Ca2+ signaling in circadian clock system. In mammals, circadian Ca2+ signaling is transduced by CaMKII that phosphorylates CLOCK to promote E-box-dependent gene expression (Kon et al., Genes and Development, 2014). Recently, we found that Na+/Ca2+ exchanger (NCX) mediates cold Ca2+ signaling for temperature compensation, and the role of NCX is conserved among mammals, insects, plants and cyanobacteria (Kon et al., Science Advances, 2021). The study suggests that Ca2+ signaling was involved in ancestral clock system. In order to investigate a hierarchical structure in the clock system, we developed mammalian cellular and fruit fly models that lost transcriptional rhythms without disrupting genes encoding the clock-related transcriptional factors. In the mammalian cells, expression of known clock genes was not sufficient to generate autonomous transcriptional rhythms of Per2 and Bmal1. Importantly, their anti-phasic expression rhythms were sustained by once-daily activation of Ca2+ signaling. The forced oscillation of transcriptional circuits was also observed in Drosophila mutant of Ca2+ signaling. Importantly, we found that circadian Ca2+ rhythms were present in mammalian cells lacking Bmal1. These results lead a novel clock model that the circadian transcriptional circuits are sustained by Ca2+ oscillation. | |||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||
| 内容記述 | EBRS2025 | |||||||
| 発表年月日 | ||||||||
| 日付 | 2025-08-24 | |||||||
