WEKO3
アイテム
Analyzing the photoactivation mechanism of photoactivated adenylate cyclase OaPAC by hybrid QM/MM simulation
https://repo.qst.go.jp/records/2002160
https://repo.qst.go.jp/records/2002160044ff564-615a-49ff-aaa2-999d4d949894
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-08-20 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Analyzing the photoactivation mechanism of photoactivated adenylate cyclase OaPAC by hybrid QM/MM simulation | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6670 | |||||||||||||||||
| 資源タイプ | conference poster | |||||||||||||||||
| 著者 |
Taguchi Masahiko
× Taguchi Masahiko
× Fukuda Akiya
× Sakuraba Shun
× Wai Soon Chan
× Nango Eriko
× Kono Hidetoshi
|
|||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述 | OaPAC is a photoactivated cAMP synthase consisting of two peptides, each of the photoreceptor and enzyme domains, via long coiled-coil helices called 3 [1,2]. It is thought that during photoactivation, the hydrogen bonding network reorganization between Tyr6, Gln48, and chromophore and keto-enol tautomerization of Gln48 occur in the photoreceptor domain [3,4]. However, the free-energy profile of the photo-isomerization reaction and how the structural change in the photoreceptor domains propagate and control the catalytic domains upon photoactivation have yet to be understood. | |||||||||||||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||||||||||||
| 内容記述 | Quantum Innovation 2025（QI2025 ） | |||||||||||||||||
| 発表年月日 | ||||||||||||||||||
| 日付 | 2025-07-29 | |||||||||||||||||
