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光子線と重粒子線の抗腫瘍免疫応答の比較
https://repo.qst.go.jp/records/2002125
https://repo.qst.go.jp/records/20021253e8170a3-bfa3-4b4a-bea8-d6913dfac7be
| アイテムタイプ | 会議発表用資料 / Presentation(1) | |||||||
|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-09-01 | |||||||
| タイトル | ||||||||
| タイトル | 光子線と重粒子線の抗腫瘍免疫応答の比較 | |||||||
| 言語 | ja | |||||||
| 言語 | ||||||||
| 言語 | jpn | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||||
| 資源タイプ | conference presentation | |||||||
| 著者 |
武島 嗣英
× 武島 嗣英
|
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| 抄録 | ||||||||
| 内容記述 | Radiotherapy reduces tumor size not only by inducing DNA damage and cell death but also by stimulating antitumor immune responses. While such effects have been well studied following conventional X-ray irradiation, little is known about immune activation after carbon-ion (C-ion) irradiation. This study aimed to compare the contribution of cytotoxic T lymphocytes (CTLs) to tumor control between X-ray and C-ion treatments. Using B16-OVA tumor-bearing C57BL/6 mice, we irradiated tumors with X-rays (10–20 Gy) or C-ions (5–10 Gy), with or without anti-CD8 antibody to deplete CTLs. Tumor growth curves showed faster progression in CD8-depleted mice, indicating CTL involvement in both modalities. Regression analysis comparing radiation dose and tumor growth delay revealed a greater CTL-dependent effect in C-ion–treated mice than in X-ray–treated mice. These results were reproducible in independent experiments. Our findings suggest that carbon-ion radiotherapy induces stronger CTL-mediated tumor suppression than X-ray therapy. This information could guide the development of optimized combinatorial immunotherapies tailored to each radiation modality. | |||||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||||
| 内容記述 | 2024年度HIMAC共同利用研究成果発表会 | |||||||
| 発表年月日 | ||||||||
| 日付 | 2025-05-26 | |||||||
