| アイテムタイプ |
会議発表論文 / Conference Paper(1) |
| 公開日 |
2025-10-27 |
| タイトル |
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タイトル |
Evaluation of Myocardial Fibrosis and Wall Motion Abnormality with 68Ga-FAPI PET/MR in Coronary Heart Disease |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_5794 |
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資源タイプ |
conference paper |
| アクセス権 |
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アクセス権 |
metadata only access |
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アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Rui Luo
Zhenyu Zhao
Chuan Zhang
Ru-Shuai Li
Qingle Meng
Yudan Ni
Rui Yang
Xin Chen
Xie Lin
Zhang Ming-Rong
Feng Wang
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Aim/Introduction: Quantification of myocardial fibrosis and wall motion assessment are crucial for prognostic evaluation in coronary heart disease (CHD). To explore the characteristics of cardiac fibroblast activation protein inhibitor (FAPI) PET/MR in CHD and its association with abnormal wall motion. Materials and Methods: In this prospective study from May 2023 to December 2023, participants with CHD underwent cardiac gallium 68(68Ga)-labeled FAPI PET/MR imaging. FAP signal (FAPI active) was quantified using regional standardized uptake values (SUVs). Cardiac MRI yielded functional parameters and area of injury (late gadolinium enhancement [LGE]) (MRI non-viable). Abnormal wall motion identified by myocardial strain analysis was evaluated using integrated analysis of LGE and FAP signal. The correlations between FAP signal and clinical parameters were explored and fibrosis was confirmed by histopathological analysis of partially resected myocardium. Results: Forty-two participants (mean age, 59 years ± 13 [SD]; 32 men) were included. The FAP signal was higher in left ventricle regional myocardium compared with remote normal areas (SUVmax, 5.0 ± 1.8 vs 1.2 ± 0.4; p < .001). In total, 432 segments (432/714, 60.50%) displayed impaired wall motion. In integrated analysis, the highest wall motion abnormality score was observed in the FAPI active/MRI non-viable group (11.0 ± 5.2). FAP signal was positively correlated with K time (SUVpeak: R = 0.48; p = .046; SUVmean: R = 0.57; p = .014) and negatively correlated with Angle (SUVpeak: R = −0.52; p = .026; SUVmean: R = −0.56; p = .026) in thromboelastography. Immunohistochemical analysis revealed FAP-positive fibroblasts in the infarct and border zone, and robust expression of α-smooth muscle actin and vimentin. Conclusion: Simultaneous 68Ga-fibroblast activation protein inhibitor PET/MR offers novel insights into the regional pattern of fibroblast activation in patients with coronary heart disease, and the fibroblast activation protein signal is associated with abnormal wall motion. |
| 書誌情報 |
EANM'25 Abstracts
巻 S1,
号 S1013,
p. S334,
発行日 2025-10
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| 出版者 |
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出版者 |
Elesever |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1016/S3051-2913(25)00004-7 |
