| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2026-01-14 |
| タイトル |
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|
タイトル |
Striatal astrocytes modulate behavioral flexibility and whole-body metabolism in mice. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Enrica Montalban
Anthony Ansoult
Daniela Herrera Moro Chao
Cuong Pham
Clara Franco
Andrea Contini
Julien Castel
Rim Hassouna
Marene H Hardonk
Anna Petitbon
Ewout Foppen
Giuseppe Gangarossa
Pierre Trifilieff
Dongdong Li
Serge Luquet
Claire Martin
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Brain circuits in reward-associated behaviors are potent drivers of feeding behavior but also recently emerged as regulator of metabolism. Short or chronic exposures to caloric food alter brain structures and are associated with increased astrocytes reactivity and pro-inflammatory responses in both mice and humans. However, the role of striatal astrocytes in regulating adaptive and maladaptive behavioral and metabolic responses to energy-dense food remains elusive. In this study we reveal that chemogenetic manipulation of the astrocytes in striatal structures can exert a direct effect on peripheral metabolism in male mice, and that manipulation of astrocytes in the dorsal striatum can alter peripheral metabolism and is sufficient to restore cognitive deficit induced by chronic high fat high sucrose (HFHS) diet exposure in obese mice. Altogether, this work reveals a yet unappreciated role for striatal astrocytes as a direct operator of flexible behavior and metabolic control. |
| 書誌情報 |
Nature communications
巻 16,
号 1,
p. 5417,
発行日 2025-07
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2041-1723 |
| PubMed番号 |
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|
識別子タイプ |
PMID |
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|
関連識別子 |
40624006 |
| DOI |
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|
識別子タイプ |
DOI |
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関連識別子 |
10.1038/s41467-025-60968-y |
