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Forced Oscillation of Circadian Transcriptional Circuits
https://repo.qst.go.jp/records/2001980
https://repo.qst.go.jp/records/200198067be1ec8-7de6-499c-b6a3-674e2760cd45
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2026-01-15 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Forced Oscillation of Circadian Transcriptional Circuits | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Iizuka Kosuke
× Iizuka Kosuke
× Kuno Masaya
× Kon Naohiro
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Circadian rhythms are based on transcriptional circuits by clock genes. Accumulating evidence indicates an existence of unidentified oscillator independent of the clock genes, although the mechanism has been unclear. Here, we show that circadian Ca2+ rhythms mediate forced oscillations of the transcriptional circuits. Circadian Ca2+ oscillation is observed in the cells lacking Bmal1 or Cry1/2. Newly developed non-rhythmic cell models revealed that clock gene expression was insufficient to generate autonomous oscillations of transcription and Ca2+. Importantly, transcriptional oscillations of Per2 and Bmal1 were sustained by artificial induction of daily Ca2+ signaling. CaMKII-CLOCK axis is a basic pathway for oscillations of the transcriptional circuits by circadian Ca2+ signaling. These results illustrate a novel clock model that the circadian transcriptional circuits are driven by Ca2+-dependent forced oscillation. | |||||||||||
| 書誌情報 |
Science 発行日 2026-01 |
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| 出版者 | ||||||||||||
| 出版者 | AAAS | |||||||||||
