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Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study
https://repo.qst.go.jp/records/2001972
https://repo.qst.go.jp/records/20019729eb349a0-73bc-483d-9c1c-c1f65b49942a
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2026-01-13 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Pre-CBT resting-state connectivity and white matter integrity in OCD remission: A multimodal MRI study | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
池水 結輝
× 池水 結輝
× 大田 淳子
× 平野 好幸
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | BackgroundObsessive-compulsive disorder (OCD) is commonly treated with cognitive-behavioral therapy (CBT), yet many patients fail to achieve remission. Neuroimaging markers, such as pre-treatment functional and structural connectivity, may help elucidate OCD pathology and CBT mechanisms, and predict treatment outcomes. This study investigates the relationship between pre-treatment functional and structural connectivity and remission status in OCD patients following CBT.MethodsThirty-three OCD patients underwent multimodal MRI, including resting-state fMRI to assess pre-treatment functional connectivity and diffusion tensor imaging (DTI) to evaluate white matter integrity. Functional connectivity multivariate pattern analysis (fc-MVPA) identified patterns linked to treatment outcomes. TRACULA, a probabilistic tractography technique, analyzed white matter tracts, focusing on diffusion metrics such as fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD). Analysis of covariance (ANCOVA) was used to examine group differences.ResultsRemission was associated with significantly higher pre-treatment resting-state functional connectivity between the occipital pole and lateral occipital cortex (height threshold: p < 0.001 uncorrected and cluster threshold: p < 0.05 cluster-size FDR corrected for multiple comparisons), suggesting a role in visual processing. Differences in white matter integrity were found in the corpus callosum rostrum, left acoustic radiation, right dorsal cingulum bundle, and right superior longitudinal fasciculus II, though these results were not corrected for multiple comparisons.ConclusionEnhanced pre-treatment functional connectivity in visual processing regions and specific white matter tracts may serve as biomarkers for remission in OCD following CBT. These findings could improve understanding of CBT’s neural effects and guide personalized treatment strategies. | |||||||||||
| 書誌情報 |
NeuroImage: Reports 巻 5, 号 3, p. 100275-100275, 発行日 2025-09 |
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| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1016/j.ynirp.2025.100275 | |||||||||||
