| アイテムタイプ |
会議発表論文 / Conference Paper(1) |
| 公開日 |
2025-06-02 |
| タイトル |
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タイトル |
Evaluation of Physiological Characteristics of in vivo AGN Probe Using Multimodal Imaging |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_5794 |
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資源タイプ |
conference paper |
| アクセス権 |
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|
アクセス権 |
metadata only access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_14cb |
| 著者 |
Koyasu Norikazu
Yatabe Hiroyuki
Takakusagi Yoichi
Saito Yutaro
Sando Shinsuke
Murali C. Krishna
Yamamoto Kazutoshi
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Motivation: Monitoring the enzymatic activity of APN in tumors non-invasively can improve cancer diagnostics and therapy. A hyperpolarized AGN probe is a key biomarker for APNGoal(s): This study aimed to validate the physiological characteristics of AGN probes in vivoApproach: We used hyperpolarized C MRS and EPSI to measure APN activity in tumors with varying APN expression. DCE-MRI, DWI, and EPRimaging to evaluate several tumor physiological parametersResults: The AGN probe distinguished high and low APN-expressing tumors, even in low permeability and hypoxic regions, showing promise forpersonalized cancer treatmentImpact: The hyperpolarized AGN probe provides a novel, non-invasive method for real-time monitoring of APN activity in tumors, even in hypoxic and low-perfusion regions, thus providing therapeutic strategies and personalized cancer treatment |
| 書誌情報 |
Proc. ISMRM
巻 in press,
発行日 2025-05
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