| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-04 |
| タイトル |
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タイトル |
Low-background Alpha Imaging System Using a CMOS Camera with Suppressed Dark Current |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Segawa Mariko
Nishinaka Ichiro
Maeda Makoto
Toh Yosuke
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Targeted alpha therapy (TAT) using short-lived radionuclides like ²¹¹At demands rapid and quantitative analysis of both activity and chemical forms across a wide dynamic range. However, existing imaging systems such as imaging plates (IPs) or standard CMOS-based setups suffer from significant noise accumulation and demand long measurement times, particularly under low-activity conditions. We report on the development of NuS-AGS, a low-background alpha imaging system using a CMOS sensor with hardware-level dark current suppression. Compared to a conventional CMOS camera, NuS-AGS exhibited ~97% suppression of dark signal accumulation up to 200 seconds without the need for post-processing subtraction. The system achieved 148 μm spatial resolution, excellent linearity (R² = 0.996) for 1.10–6.60 kBq of 211At, and stable half-life measurements consistent with ²¹¹At. Moreover, it resolved three chemical species of ²¹¹At using thin-layer chromatography within 10 minutes, significantly outperforming IPs (2.8% of measurement time). These results demonstrate that NuS-AGS enables high-sensitivity, low-background alpha imaging suitable for both radiochemical research and clinical quality control workflows. |
| 書誌情報 |
Journal of Instrumentation
巻 20,
号 10,
発行日 2025-10
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| 出版者 |
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出版者 |
IOP Publishing |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1088/1748-0221/20/10/p10048 |
