| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-21 |
| タイトル |
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タイトル |
Development of a submillimeter resolution PET scanner with compact geometry for hybrid multi-photon/PET imaging |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hangyu Kang
Takuwa Hiroyuki
Tashima Hideaki
Wakizaka Hidekatsu
Higuchi Makoto
Yamaya Taiga
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Objective. For mouse brain research, multi-modal imaging techniques are important to understand neurodegenerative mechanisms with different informational aspects. The aim of this study is to develop a submillimeter resolution positron emission tomography (PET) scanner of compact geometry that can be integrated with a commercial multi-photon excitation microscope. Methods.The PET scanner has ring diameter of 52.5 mm and 24.5 mm axial length. We employed three-layer LYSO crystals (with individual crystal layer thicknesses of 4, 4 and 7 mm) with a 1 mm crystal pitch and a 4 × 4 silicon photomultiplier array. The physical PET performance was evaluated in line withthe National Electrical Manufacturers Association NU 4-2008 protocol. In vivo mouse brain imaging was performed with 18F-FITM tracer. Main results. The spatial resolution was 0.89 mm, and sensitivity was 0.85% at the center with an energy window of 440–560 keV. The detailed mouse brain structures were clearly resolved, although they were hardly identifiable with a commercial preclinical PET scanner. Significance. The submillimeter resolution PET scanner with the compact geometry outperformed the commercial preclinical PET scanner. In the near future, we will integrate this high-resolution PET scanner with a multi-photon microscopy system for simultaneous multi-photon/PET imaging of mouse brain. |
| 書誌情報 |
Physics in Medicine and Biology
巻 70,
号 17,
発行日 2025-08
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0031-9155 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1088/1361-6560/adf9b6 |
