| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-11-04 |
| タイトル |
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タイトル |
Radiation-induced transformation of peptides into nanoparticles for nano-theranostics of pancreatic cancer with controllable drug delivery and sustained release |
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言語 |
ja |
| 言語 |
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言語 |
jpn |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
木村 敦
濱口 裕貴
大山 廣太郎
田 超中
山下 真一
田口 光正
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Nano-theranostics using biodegradable polymers are effective for the diagnosis and treatment of intractable cancers, but there is a need for technology that can control its bioavailability and biodegradability without compromising its biocompatibility. Peptide nanoparticles with controlled particle size and biodegradability were prepared by ionizing radiation and loaded with imagining agents and anticancer drugs to develop novel nano-theranostics for pancreatic cancer diagnosis and treatment in this study. Peptides composed of histidine, glycine, glutamic acid, and arginine-glycine-aspartic acid (RGD motif) were synthesized by solid synthesis method, and its aqueous solutions were irradiated by γ-rays to produce their nanoparticles with a particle size less than 50 nm, which can penetrate the pancreatic cancer stroma. Radiation crosslinking of peptides with or without RGD motif in water were investigated by pulse radiolysis experiments. The peptide nanoparticles loaded with fluorescent labeling agents or MRI imaging agents were efficiently taken up by pancreatic cancer cells. The cisplatin loaded peptide nanoparticles produced by higher dose irradiation suppressed drug release rates due to their lower biodegradability. Peptide nanoparticles controlled their particle size and biodegradability were produced by using ionizing radiation method and were loaded with a fluorescent labeling agent, a MRI imaging agent, and an anticancer drug to develop a new nano-theranostics drug for pancreatic cancer diagnosis and treatment. |
| 書誌情報 |
Free Radical Research
発行日 2025-11
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| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1080/10715762.2025.2580607 |
