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Automated Radiosynthesis of [18F]FMeNER-D2 Using the Simplified One-Pot 18F-Fluoromethylation Method
https://repo.qst.go.jp/records/2001850
https://repo.qst.go.jp/records/200185040cba1ab-30c2-4187-b1ba-7be314ae3149
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||||||||||
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| 公開日 | 2025-08-18 | |||||||||||||||||||||||||||||||||||
| タイトル | ||||||||||||||||||||||||||||||||||||
| タイトル | Automated Radiosynthesis of [18F]FMeNER-D2 Using the Simplified One-Pot 18F-Fluoromethylation Method | |||||||||||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||||||||||
| 著者 |
Kawamura Kazunori
× Kawamura Kazunori
× Mori Wakana
× Yusuke Kurihara
× Ogawa Masanao
× Hashimoto Hiroki
× Takayuki Ohkubo
× Tsukagoe Kaito
× Tomoya Fujishiro
× Arashi Daisuke
× Sato Tatsuto
× Seki Takeru
× Muto Masatoshi
× Nengaki Nobuki
× Fujinaga Masayuki
× Zhang Ming-Rong
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| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||||||||||
| 内容記述 | (S,S)-2-(α-(2-[18F]Fluoro[dideutero]methoxyphenoxy)benzyl)morpholine ([18F] FMeNER-D2), which is used to image the norepinephrine transporter in the brain via positron emission tomography (PET), is typically radiosynthesized by O-fluoromethylating norethylreboxetine (NER) with [18F]bromofluoromethane-d2 using a fully automated 18F-labeling synthesizer with a two-pot unit. We simplified the automated radiosynthesis of [18F]FMeNER-D2 through the use of a straightforward one-pot method to prepare [18F]fluoromethyl-d2-tosylate as the fluoromethylating agent (avoiding the need to azeotropically dry [18F]F− in advance), which was then reacted with NER. The reaction conditions were optimized, with [18F]FMeNER-D2 synthesized using an 18Flabeling synthesizer equipped with a one-pot unit. As a result, a synthesis time, radiochemical yield based on total [18F]F−, molar activity, and radiochemical purity of 66±4.7min (n=7), 9.0%±0.8% (n=3), 130–275GBq/μmol (n=7), and >97% (n=7), respectively, were obtained at the end of synthesis. In conclusion, we successfully synthesized [18F]FMeNER-D2 using a simplified one-pot, fully automated, 18F-fluoromethylation method in an 18F-labeling synthesizer. | |||||||||||||||||||||||||||||||||||
| 書誌情報 |
Journal of Labelled Compounds and Radiopharmaceuticals 発行日 2025-08 |
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| 出版者 | WILEY | |||||||||||||||||||||||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||||||||||||||||||||||
| 収録物識別子 | 1099-1344 | |||||||||||||||||||||||||||||||||||
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||||||||||
| 関連識別子 | 10.1002/jlcr.4161 | |||||||||||||||||||||||||||||||||||
