| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-10-09 |
| タイトル |
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タイトル |
Production of 211At and Automated Radiosynthesis of [211At]MABG via Electrophilic Astatodesilylation |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yuto Kondo
Taiki Joho
Shigenori Sasaki
Kazumasa Mochizuki
Naoko Hasegawa
Naoyuki Ukon
Ken-ichi Nishijima
Kohshin Washiyama
Hiroshi Tanaka
Higashi Tatsuya
Ishioka Noriko
Kazuhiro Takahashi
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
[211At]m-Astatobenzylguanidine ([211At]MABG) has demonstrated potent antitumor efficacy in preclinical models of malignant neuroendocrine tumours. The high linear energy transfer and short tissue penetration range of alpha particles enable highly localized cytotoxic effects, potentially overcoming therapeutic limitations associated with conventional beta-emitting radiopharmaceuticals. However, under clinical-scale (i.e., high radioactivity) conditions, the efficient and stable production of [211At]MABG has been hindered by radiolytic degradation during the manufacturing process limiting the availability of reliable methods offering high radiochemical yield and purity. In this study, we aimed to develop a scalable production methodology for [211At]MABG suitable for clinical translation. |
| 書誌情報 |
EJNMMI Radiopharmacy and Chemistry
発行日 2025-10
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| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1186/s41181-025-00376-1 |
