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Advances in malignant hyperthermia: novel insights into heat-induced Ca2+ release as a thermal signaling
https://repo.qst.go.jp/records/2001778
https://repo.qst.go.jp/records/2001778e9277305-d56a-4bd7-9989-c8a987882d05
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||
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| 公開日 | 2025-09-04 | |||||||||||
| タイトル | ||||||||||||
| タイトル | Advances in malignant hyperthermia: novel insights into heat-induced Ca2+ release as a thermal signaling | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | eng | |||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
| 資源タイプ | journal article | |||||||||||
| 著者 |
Toshiko Yamazawa
× Toshiko Yamazawa
× Oyama Kotaro
× Madoka Suzuki
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| 抄録 | ||||||||||||
| 内容記述タイプ | Abstract | |||||||||||
| 内容記述 | Thermoregulation is essential for maintaining homeostasis in mammals under various environmental conditions. Impairment of this function can result in severe conditions, such as fever, heat stroke, and malignant hyperthermia (MH). In this review, we will focus on the role of the type 1 ryanodine receptor (RYR1), a Ca2+ release channel that is crucial for excitation-contraction coupling in skeletal muscles. Mutations in RYR1 are associated with muscle disorders, including MH, which is characterized by dysregulated Ca2+-induced Ca2+ release (CICR). Recent advances from genetically engineered mouse models of MH have provided new insights into the pathophysiological mechanisms underlying anesthetic- and heat-induced episodes, and revealed a heat-induced Ca2+ release (HICR) mechanism mediated by RYR1. Experimental evidences demonstrate that anesthetics induce simultaneous increases in cellular temperature and cytosolic Ca2+ concentration. Therefore, this review proposes that an increase in cellular temperature triggers further Ca2+ release via HICR, establishing a positive feedback loop that sustains excessive heat production during MH crises. | |||||||||||
| 書誌情報 |
Journal of Smooth Muscle Research 巻 61, p. 65-74, 発行日 2025-09 |
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| DOI | ||||||||||||
| 識別子タイプ | DOI | |||||||||||
| 関連識別子 | 10.1540/jsmr.61.65 | |||||||||||
