| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-08-25 |
| タイトル |
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|
タイトル |
Enhanced cytotoxicity against cancer cells by acetylation of a planar catechin analog |
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言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ito Hiromu
Shoji Yoshimi
Itabashi Yuki
Matsumoto Kenichiro
Ohkubo Kei
Fukuhara Kiyoshi
Nakanishi Ikuo
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
Catechin is a major antioxidant and also shows anti-cancer effect. We have synthesized a catechin analog possessing a planar structure, planar catechin, which has 10-fold larger radical-scavenging activity than the parental (+)-catechin. However, the planar catechin has a possibility to lose the innate activity before reaching target cells, because of the higher reactivity. In this study, we introduced acetyl groups to the phenolic hydroxy groups, in order to protect from the oxidation of the planar catechin. The acetylated planar catechin showed a remarkable cytotoxicity compared to the original planar catechin, especially in cancer cells. Furthermore, after the acetylated planar catechin was treated with esterase, the enhanced superoxide scavenging activity was confirmed by an electron paramagnetic resonance technique. These results indicate that the activity of the planar catechin was maintained by acetylation and the deprotection by intracellular esterase restored the activity, leading to the induction of the severe cytotoxicity. |
| 書誌情報 |
Free Radical Research
巻 59,
号 6-7,
p. 480-486,
発行日 2025-07
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| 出版者 |
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出版者 |
Taylor & Francis |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1080/10715762.2025.2525185 |
