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内容記述 |
The small intestine is an important organ responsible for the absorption of orally ingested substances. The luminal surface of the intestinal tract is covered with the villi, which plays an important role as the first step in absorption. The elemental distribution in the fine structure of the intestine, however, has not been clearly understood. Micro-PIXE (particle-induced X-ray emission) is good at detecting light elements and is suitable for elemental distribution analysis of biological tissues. SR-XRF (synchrotron radiation X-ray fluorescence), on the other hand, is superior in detecting heavy metals. In this study, intestinal elemental distribution was examined in mice administered to cesium (Cs) by combination of micro-PIXE analysis for endogenous phosphorus (P), potassium (K), and sulfur (S) and SR-XRF analysis using high-energy synchrotron radiation for Cs. Elemental distributions corresponding to the luminal structure were obtained with cross sections of the small intestine; P, K, S was higher in the villi than in the basal region in the intestine of the control mice. Cs administration did not significantly alter the distribution of these elements. Cs was also higher in the villi than in the basal region in the intestine and found in the center area of the villi, where the lamina propria and capillary vessels of circulation are distributed, with higher magnification analysis. The present method is useful for studying the intestinal dynamics of Cs distribution.Cesium, intestine, PIXE, SR-XRF |
