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SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots
https://repo.qst.go.jp/records/2001431
https://repo.qst.go.jp/records/2001431ba37b261-c86f-4d40-9fca-5b3b27c9d1e8
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2025-07-10 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | SUPPRESOR OF GAMMA RESPONSE 1 promotes early onset of endoreplication upon DNA double-strand breaks by inducing CCS52A1 expression in Arabidopsis roots | |||||||||||||
| 言語 | en | |||||||||||||
| 言語 | ||||||||||||||
| 言語 | eng | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| 著者 |
Wada Toshiki (Meiji Univ.)
× Wada Toshiki (Meiji Univ.)
× Sakamoto Ayako
× Masaaki Umeda (NAIST)
× Takahashi Naoki (Meiji Univ.)
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| 抄録 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Living organisms are constantly at the risk of DNA damage caused by factors such as DNA replication errors, reactive oxygen species, and UV radiation. In plants, DNA damage activates the NAC-type transcription factor SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) that governs DNA damage responses such as cell cycle arrest, stem cell death, and early onset of endoreplication. However, molecular mechanisms underlying the early induction of endoreplication onset in response to DNA damage remain elusive. In this study, we show that CELL CYCLE SWITCH 52 A1 (CCS52A1), an activator of the APC/C E3 ligase, plays a major role in the early onset of endoreplication in response to DNA double-strand breaks (DSBs) in Arabidopsis roots. Upon DSBs, SOG1 directly binds to the CCS52A1 locus, thereby inducing its expression. Moreover, early transition to endoreplication in response to DSBs is suppressed in ccs52a1 knockout roots. Our data propose that increased polyploidy may function as a unique adaptative mechanism to genotoxic stress in plants. | |||||||||||||
| 書誌情報 |
Journal of Plant Research 巻 138, p. 679-693, 発行日 2025-04 |
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| 出版者 | Springer | |||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||
| 収録物識別子 | 0918-9440 | |||||||||||||
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| 識別子タイプ | PMID | |||||||||||||
| 関連識別子 | 40192898 | |||||||||||||
| DOI | ||||||||||||||
| 識別子タイプ | DOI | |||||||||||||
| 関連識別子 | 10.1007/s10265-025-01630-y | |||||||||||||
