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Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques
https://repo.qst.go.jp/records/2001402
https://repo.qst.go.jp/records/200140205e46623-d6bd-435b-bc0a-5804eca40ecb
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||||||||
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| 公開日 | 2024-12-19 | |||||||||||||||||||||||||||
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| タイトル | Cross-Species Convergence of Functional Connectivity Changes in Thalamic Pain Across Human Patients and Model Macaques | |||||||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||||||||
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| 言語 | eng | |||||||||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||||||||
| 著者 |
Dong Dong
× Dong Dong
× Koichi Hosomi
× Takeshi Shimizu
× Ken-ichi Okada
× Yoshinori Kadono
× Nobuhiko Mori
× 堀 祐樹
× 八幡 憲明
× 平林 敏行
× Haruhiko Kishima
× Youichi Saitoh
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| 抄録 | ||||||||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||||||||
| 内容記述 | Abstract: Thalamic pain can be understood as a network reorganization disorder. This study aimed to investigate functional connectivity (FC) in human patients and a macaque model of thalamic pain. In humans, resting-state FC was compared between patients with thalamic pain and healthy individuals. Furthermore, resting-state FC was compared in macaques, before and after the induction of thalamic pain in the same individuals. FC between the amygdala of the unaffected hemisphere and the brainstem was significantly higher in patients with thalamic pain. More specifically, a significantly higher FC was observed between the basolateral amygdala and the ventral tegmental area, which also significantly predicted the value of a visual analog scale of pain intensity in individual patients. The macaque model of thalamic pain also exhibited a significantly higher FC between the amygdala of the unaffected hemisphere and the brainstem, particularly between the basolateral amygdala and the midbrain. Furthermore, the previously reported significantly higher FC between the amygdala and the mediodorsal nucleus of the thalamus in macaques with thalamic pain was also reproduced in the human patients. Therefore, the present results suggest that the FC changes in the regions associated with emotion, memory, motivation, and reward are part of the underlying mechanisms of thalamic pain onset present in both human patients and model macaques. This cross-species convergence provides new insights into the neurological mechanisms underlying thalamic pain, paving the way for further studies and the development of therapeutic strategies. Perspective: This article presents that the FC changes in the regions associated with emotion, motivation, and reward are part of the underlying mechanisms of thalamic pain in humans and macaques. |
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| 書誌情報 |
The Journal of pain 巻 25, 号 12, 発行日 2024-12 |
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| 識別子タイプ | DOI | |||||||||||||||||||||||||||
| 関連識別子 | 10.1016/j.jpain.2024.104661 | |||||||||||||||||||||||||||
