| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-06-12 |
| タイトル |
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|
タイトル |
Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy. |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Shan Gao
Yutaka Miura
Akira Sumiyoshi
Satoshi Ohno
Keisuke Ogata
Takahiro Nomoto
Makoto Matsui
Yuto Honda
Minoru Suzuki
Megumi Iiyama
Kensuke Osada
Ichio Aoki
Nobuhiro Nishiyama
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Nano-sized contrast agents (NCAs) hold potential for highly specific tumor contrast enhancement during magnetic resonance imaging. Given the quantity of contrast agents loaded into a single nano-carrier and the anticipated relaxation effects, the current molecular design approaches its limits. In this study, a novel molecular mechanism to augment the relaxation of NCAs is introduced and demonstrated. NCA formation is driven by the intramolecular self-folding of a single polymer chain that possesses systematically arranged hydrophilic and hydrophobic segments in water. Utilizing this self-folding molecular design, the relaxivity value can be elevated with minimal loading of gadolinium complexes, enabling sharp tumor imaging. Furthermore, the study reveals that this NCA can selectively accumulate into tumor tissues, offering effective anti-tumor results through gadolinium neutron capture therapy. The efficacy and versatility of this self-folding molecular design underscore its promise for cancer diagnosis and treatment. |
| 書誌情報 |
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
巻 11,
号 7,
p. 2304171,
発行日 2023-11
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| 出版者 |
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出版者 |
Wiley |
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
2198-3844 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
38030413 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1002/advs.202304171 |
