| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-04-23 |
| タイトル |
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|
タイトル |
Effects of whole-body carbon-ion beam irradiation on bone marrow death in mice and an examination of candidates for protectors or mitigators against carbon-ion beam-induced bone marrow death |
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言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ueno Megumi
Setoguchi Shuichi
Matsunaga Kazuhisa
Matsumoto Ken-ichiro
Takata Jiro
Anzai Kazunori
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| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
The present study examined the effects of whole-body carbon-ion beam irradiation on bone marrow death in mice and investigated whether compounds/materials, which were identified as efficient radio-protectors or mitigators against X-ray irradiation-induced bone marrow death, were also effective against the carbon-ion beam-induced death of mice. Amifostine and cysteamine were used as radio-protectors and zinc-containing heat-killed yeast (Zn-yeast) and γ-tocopherol-N,N-dimethylglycine ester (γTDMG) as radio-mitigators. Amifostine or cysteamine was intraperitoneally administered in a single injection of 1.95 mmol/kg body weight 30 min before whole-body carbon-ion beam irradiation. Zn-yeast or γTDMG was administered in a single intraperitoneal injection of 100 mg/kg body weight immediately after whole-body carbon-ion beam irradiation. The absorbed dose dependence of the 30-day survival rate after carbon-ion beam irradiation was analyzed. The biological effectiveness of carbon-ion beam irradiation (LD50/30 = 5.54 Gy) was estimated as 1.2 relative to X-ray irradiation (LD50/30 = 6.62 Gy). The dose reduction factors (DRF) of amifostine, cysteamine, Zn-yeast, and γTDMG estimated for carbon-ion beam irradiation were 1.75, 1.53, 1.16, and 1.15, respectively. Radio-protectors and -mitigators that were effective against photon irradiation also exhibited efficacy against carbon-ion beam irradiation; however, the DRF for carbon-ion beam irradiation was slightly smaller than that for photon irradiation. Based on the radio-protective effects of amifostine and cysteamine, the contribution of ROS/free radicals to carbon-ion beam-induced bone marrow death was 70?90% of that to photon irradiation. Since the suppression of tumor growth by carbon-ion beam irradiation was not inhibited by the treatment with γTDMG or Zn-yeast, both mitigators have potential as normal tissue-selective protectors in carbon-ion radiation therapy. |
| 書誌情報 |
Radiation Research
巻 203,
号 4,
p. 246-256,
発行日 2025-02
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| 出版者 |
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出版者 |
Radiation Research Society |
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
1938-5404 |
| PubMed番号 |
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識別子タイプ |
PMID |
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関連識別子 |
39933555 |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
10.1667/RADE-23-00253.1 |
