| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-04-22 |
| タイトル |
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タイトル |
Monte Carlo simulation study on the dose and dose-averaged linear energy transfer distributions in carbon ion radiotherapy |
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言語 |
en |
| 言語 |
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言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Akihisa Ishikawa
Yusuke Koba
Takuya Furuta
Weishan Chang
Shunsuke Yonai
Shinnosuke Matsumoto
Shintaro Hashimoto
Yuta Hirai
Tatsuhiko Sato
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| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
At the Heavy Ion Medical Accelerator in Chiba (HIMAC), a series of retrospective studies are ongoing in patients treated with carbon ion radiotherapy (CIRT) to obtain the knowledge to improve tumor control and reveal the mechanism of the low risk of secondary cancer after CIRT. Dose-averaged linear energy transfer (LETd) is generally used as a measure of treatment effectiveness or biological effects in such retrospective studies; however, it is conventionally evaluated from the relative biological effectiveness (RBE)-LETd fitted function used in the treatment planning system. In this study, we calculated the physical doses and their linear energy transfer (LET) distributions for a series of treatment plans for a homogeneous rectangular phantom and a human body phantom with typical CIRT beams using Monte Carlo (MC) simulation. The LETd was then deduced from the MC simulation and compared with the corresponding data obtained using the conventional method. The comparison suggested that the two types of LETd agreed well with each other, except around the distal end of the spread-out Bragg peak, where the MC simulation yielded significantly higher LETd values than that of the conventional method. This is because the RBE-LETd fitted function adopted in the conventional method ignores the contribution of the high-LET components, causing an overkill effect. Furthermore, an MC simulation was conducted to determine the material composition of water and realistic materials from the CT number in the planned image. The profiles of physical dose and LETd were in good agreement for both techniques. These results indicate the possibility of enhancing the efficiency of retrospective studies of CIRT using MC simulations in the future. |
| 書誌情報 |
Radiological Physics and Technology
発行日 2024-04
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| 出版者 |
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出版者 |
Springer Singapore |
| DOI |
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識別子タイプ |
DOI |
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関連識別子 |
https://doi.org/10.1007/s12194-024-00798-7 |
