| アイテムタイプ |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-09 |
| タイトル |
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|
タイトル |
PET reporter systems for the brain. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Sridhar Goud Nerella
Michael Michaelides
Takafumi Minamimoto
Robert B Innis
Victor W Pike
Mark A G Eldridge
|
| 抄録 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Positron emission tomography (PET) can be used as a noninvasive method to longitudinally monitor and quantify the expression of proteins in the brain in vivo. It can be used to monitor changes in biomarkers of mental health disorders, and to assess therapeutic interventions such as stem cell and molecular genetic therapies. The utility of PET monitoring depends on the availability of a radiotracer with good central nervous system (CNS) penetration and high selectivity for the target protein. This review evaluates existing methods for the visualization of reporter proteins and/or protein function using PET imaging, focusing on engineered systems, and discusses possible approaches for future success in the development of high-sensitivity and high-specificity PET reporter systems for the brain. |
| 書誌情報 |
Trends in neurosciences
巻 46,
号 11,
p. 941-952,
発行日 2023-09
|
| 出版者 |
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|
出版者 |
Elsevier Applied Science Publishing |
| ISSN |
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|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
1878-108X |
| PubMed番号 |
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|
識別子タイプ |
PMID |
|
|
関連識別子 |
37734962 |
| DOI |
|
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|
識別子タイプ |
DOI |
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|
関連識別子 |
10.1016/j.tins.2023.08.007 |
