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Event-by-event approach to the oxygen-effect incorporated stochastic microdosimetric kinetic model for hypo-fractionated multi-ion therapy
https://repo.qst.go.jp/records/2000722
https://repo.qst.go.jp/records/2000722aff60704-cffc-493e-ba66-4219011584c6
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||
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| 公開日 | 2025-01-17 | |||||||||
| タイトル | ||||||||||
| タイトル | Event-by-event approach to the oxygen-effect incorporated stochastic microdosimetric kinetic model for hypo-fractionated multi-ion therapy | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| 著者 |
Inaniwa Taku
× Inaniwa Taku
× Kanematsu Nobuyuki
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| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | An oxygen-effect incorporated stochastic microdosimetric kinetic (OSMK) model was developed previously to estimate the survival fraction of cells exposed to charged-particle beams with wide dose and linear energy transfer (LET) ranges under various oxygen conditions. In the model, hypoxia-induced radio-resistance was formulated based on the dose-averaged radiation quality. This approximation may cause inaccuracy in estimation of biological effectiveness of the radiation with wide variation in energy deposited to a sensitive volume per event such as spread-out Bragg peak (SOBP) beams. The purpose of this study was to apply an alternative approach so as to consider the energy depositions on an event-by-event basis. The production probability of radiation-induced lesions per energy was formulated with oxygen partial pressure to account for the hypoxia-induced radio-resistance. The reduction in the oxygen enhancement ratio for high-LET radiations was modeled by reducing the sensitive-volume size and increasing saturation energy in microdosimetry. The modified OSMK model was tested against reported survival data of 3 cell lines exposed to 6 species of ions with wide dose and LET ranges under aerobic and hypoxic conditions. The model reasonably reproduced the reported cell survival data. To evaluate the event-by-event approach, survival distributions of CHO cells exposed to SOBP beams were estimated using the original and modified OSMK models. Differences in the estimated survival distributions between the models were marginal even under extreme hypoxia. The event-by-event approach improved theoretical validity of the OSMK model. However, the original OSMK model can still provide accurate estimation of biological effectiveness of therapeutic radiations. | |||||||||
| 書誌情報 |
Journal of Radiation Research 巻 64, 号 ４, p. 685-692, 発行日 2023-07 |
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| 出版者 | ||||||||||
| 出版者 | Oxford University Press | |||||||||
| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 1349-9157 | |||||||||
| DOI | ||||||||||
| 識別子タイプ | DOI | |||||||||
| 関連識別子 | 10.1093/jrr/rrad049 | |||||||||
