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Multimodal laparoscopic coincidence gamma imaging system for near-infrared fluorescence guided surgery: a preclinical study
https://repo.qst.go.jp/records/2000717
https://repo.qst.go.jp/records/200071743d6a85a-667d-48b7-9af3-65a6990f31d9
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2024-11-25 | |||||||||||||||
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| タイトル | Multimodal laparoscopic coincidence gamma imaging system for near-infrared fluorescence guided surgery: a preclinical study | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Seong Hyun Song
× Seong Hyun Song
× Seong Jong Hong
× Ho Young Lee
× Hangyu Kang
× Young Been Han
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Purpose: Minimally invasive surgery (MIS) has an advantage in terms of quality of life and patient outcomes. Recently, near-infrared (NIR) fluorescence guided surgery has widely used for preclinical and clinical trials. However, NIR fluorescence has a maximum penetration capability of 10 mm. Radiographic imaging can be a solution to overcome the depth issue of NIR fluorescence. For this reason, the performance of the multimodal imaging system, which integrates annihilation gamma (511 keV) rays, NIR fluorescence, and color images, was evaluated. Approach: The multimodal imaging system was consisted of a laparoscopic module, containing an internal detector for annihilation gamma events and cameras for optical imaging, and a flat module for coincidence detection with the internal detector. The acquired images were integrated by an algorithm with post image processing and registration. To evaluate the performance of the proposed multimodal imaging system, the images of a resolution target, a square bar target filled with a fluorescence dye, and a sodium-22 point source were analyzed. A preclinical test for axillary SLN biopsy with a rat model were conducted. Results: The spatial resolution of color image was equivalent to 4 lp/mm. The MTF of NIR fluorescence at 1 lp/mm was 0.83. The 511 keV gamma sensitivity and spatial resolution of the point source were 0.54 cps/kBq and 2.1 mm, respectively. The image of 511 keV gamma rays showed almost the same intensity regardless of the thickness of the tissue phantom. In the preclinical test, integrated image of the SLN sample of the rat model was obtained with the proposed multimodal imaging system. Conclusions: With the proposed laparoscopic system, a merged image of the sample was obtained with the rat model. The annihilation gamma rays showed superior penetration capability with the tissue-mimicking phantom than NIR fluorescence. Keywords: multimodal imaging system, minimally invasive surgery, fluorescence guided surgery, annihilation gamma ray, image reconstruction, near-infrared fluorescence. |
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| 書誌情報 |
Journal of Medical Imaging 巻 10, 号 3, p. 033505-1-033505-15, 発行日 2023-06 |
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| 出版者 | SPIE | |||||||||||||||
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| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 2329-4302 | |||||||||||||||
| DOI | ||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | 10.1117/1.JMI.10.3.033505 | |||||||||||||||
